As of now, there still isn’t a clear stand on the safety of NMN supplements, especially regarding long-term use. From human trials conducted, the range of side effects reported has been quite limited often being mild digestive problems. Treating it as any other supplement, concurrent health issues alongside medication intake can pose challenges. Those pregnant or breastfeeding, alongside people with existing medical conditions or those on specific drugs should reach out to a professional before taking NMN supplements. Underlying factors such as quality control and regulatory oversight would also play a role on the level of safety.